Plasma Membrane and Transport - MCAT Biological and Biochemical Foundations of Living Systems
Card 1 of 392
Prions are the suspected cause of a wide variety of neurodegenerative diseases in mammals. According to prevailing theory, prions are infectious particles made only of protein and found in high concentrations in the brains of infected animals. All mammals produce normal prion protein, PrPC, a transmembrane protein whose function remains unclear.
Infectious prions, PrPRes, induce conformational changes in the existing PrPC proteins according to the following reaction:
PrPC + PrPRes → PrPRes + PrPRes
The PrPRes is then suspected to accumulate in the nervous tissue of infected patients and cause disease. This model of transmission generates replicated proteins, but does so bypassing the standard model of the central dogma of molecular biology. Transcription and translation apparently do not play a role in this replication process.
This theory is a major departure from previously established biological dogma. A scientist decides to test the protein-only theory of prion propagation. He establishes his experiment as follows:
Homogenized brain matter of infected rabbits is injected into the brains of healthy rabbits, as per the following table:
Rabbit 1 and 2: injected with normal saline on days 1 and 2
The above trials serve as controls.
Rabbit 3 and 4: injected with homogenized brain matter on days 1 and 2
The above trials use unmodified brain matter.
Rabbit 5 and 6: injected with irradiated homogenized brain matter on days 1 and 2
The above trials use brain matter that has been irradiated to destroy nucleic acids in the homogenate.
Rabbit 7 and 8: injected with protein-free centrifuged homogenized brain matter on days 1 and 2
The above trials use brain matter that has been centrifuged to generate a protein-free homogenate and a protein-rich homogenate based on molecular weight.
Rabbit 9 and 10: injected with boiled homogenized brain matter on days 1 and 2
The above trials use brain matter that have been boiled to destroy any bacterial contaminants in the homogenate.
Another experiment shows that PrPC reacts with hormones that circulate among nervous tissue. As a transmembrane protein, what kinds of hormones are most likely to interact with PrPC?
I. Peptide hormones
II. Catecholamines
III. Steroid Hormones
Prions are the suspected cause of a wide variety of neurodegenerative diseases in mammals. According to prevailing theory, prions are infectious particles made only of protein and found in high concentrations in the brains of infected animals. All mammals produce normal prion protein, PrPC, a transmembrane protein whose function remains unclear.
Infectious prions, PrPRes, induce conformational changes in the existing PrPC proteins according to the following reaction:
PrPC + PrPRes → PrPRes + PrPRes
The PrPRes is then suspected to accumulate in the nervous tissue of infected patients and cause disease. This model of transmission generates replicated proteins, but does so bypassing the standard model of the central dogma of molecular biology. Transcription and translation apparently do not play a role in this replication process.
This theory is a major departure from previously established biological dogma. A scientist decides to test the protein-only theory of prion propagation. He establishes his experiment as follows:
Homogenized brain matter of infected rabbits is injected into the brains of healthy rabbits, as per the following table:
Rabbit 1 and 2: injected with normal saline on days 1 and 2
The above trials serve as controls.
Rabbit 3 and 4: injected with homogenized brain matter on days 1 and 2
The above trials use unmodified brain matter.
Rabbit 5 and 6: injected with irradiated homogenized brain matter on days 1 and 2
The above trials use brain matter that has been irradiated to destroy nucleic acids in the homogenate.
Rabbit 7 and 8: injected with protein-free centrifuged homogenized brain matter on days 1 and 2
The above trials use brain matter that has been centrifuged to generate a protein-free homogenate and a protein-rich homogenate based on molecular weight.
Rabbit 9 and 10: injected with boiled homogenized brain matter on days 1 and 2
The above trials use brain matter that have been boiled to destroy any bacterial contaminants in the homogenate.
Another experiment shows that PrPC reacts with hormones that circulate among nervous tissue. As a transmembrane protein, what kinds of hormones are most likely to interact with PrPC?
I. Peptide hormones
II. Catecholamines
III. Steroid Hormones
Tap to reveal answer
Students should know that peptide hormones (and catecholamines, but this is not required to answer the question correctly as written here) interact with surface receptors and do not freely go through a membrane. They must interact with the transmembrane surface receptors to initiate a signal transduction cascade. In contrast, steroid hormones can bypass the transmembrance protein receptors by freely diffusing across the memberane, due to their small, nonpolar nature. In this case, only peptide hormones and catecholamines will require the facilitated diffusion mechanism provided by a transmembrane protein.
Students should know that peptide hormones (and catecholamines, but this is not required to answer the question correctly as written here) interact with surface receptors and do not freely go through a membrane. They must interact with the transmembrane surface receptors to initiate a signal transduction cascade. In contrast, steroid hormones can bypass the transmembrance protein receptors by freely diffusing across the memberane, due to their small, nonpolar nature. In this case, only peptide hormones and catecholamines will require the facilitated diffusion mechanism provided by a transmembrane protein.
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Scientists use a process called Flourescent In-Situ Hybridization, or FISH, to study genetic disorders in humans. FISH is a technique that uses spectrographic analysis to determine the presence or absence, as well as the relative abundance, of genetic material in human cells.
To use FISH, scientists apply fluorescently-labeled bits of DNA of a known color, called probes, to samples of test DNA. These probes anneal to the sample DNA, and scientists can read the colors that result using laboratory equipment. One common use of FISH is to determine the presence of extra DNA in conditions of aneuploidy, a state in which a human cell has an abnormal number of chromosomes. Chromosomes are collections of DNA, the totality of which makes up a cell’s genome. Another typical use is in the study of cancer cells, where scientists use FISH labels to ascertain if genes have moved inappropriately in a cell’s genome.
Using red fluorescent tags, scientists label probe DNA for a gene known to be expressed more heavily in cancer cells than normal cells. They then label a probe for an immediately adjacent DNA sequence with a green fluorescent tag. Both probes are then added to three dishes, shown below. In dish 1 human bladder cells are incubated with the probes, in dish 2 human epithelial cells are incubated, and in dish 3 known non-cancerous cells are used. The relative luminescence observed in regions of interest in all dishes is shown below.
The bladder cells in dish 1 begin to undergo programmed cell death, or apoptosis, when they initially become cancerous. If the cells form sodium-selective pores in their membranes to begin the process of cell death, sodium ions can begin to enter the cells without regulation. What will likely happen to a resting cell membrane potential when sodium enters?
Scientists use a process called Flourescent In-Situ Hybridization, or FISH, to study genetic disorders in humans. FISH is a technique that uses spectrographic analysis to determine the presence or absence, as well as the relative abundance, of genetic material in human cells.
To use FISH, scientists apply fluorescently-labeled bits of DNA of a known color, called probes, to samples of test DNA. These probes anneal to the sample DNA, and scientists can read the colors that result using laboratory equipment. One common use of FISH is to determine the presence of extra DNA in conditions of aneuploidy, a state in which a human cell has an abnormal number of chromosomes. Chromosomes are collections of DNA, the totality of which makes up a cell’s genome. Another typical use is in the study of cancer cells, where scientists use FISH labels to ascertain if genes have moved inappropriately in a cell’s genome.
Using red fluorescent tags, scientists label probe DNA for a gene known to be expressed more heavily in cancer cells than normal cells. They then label a probe for an immediately adjacent DNA sequence with a green fluorescent tag. Both probes are then added to three dishes, shown below. In dish 1 human bladder cells are incubated with the probes, in dish 2 human epithelial cells are incubated, and in dish 3 known non-cancerous cells are used. The relative luminescence observed in regions of interest in all dishes is shown below.
The bladder cells in dish 1 begin to undergo programmed cell death, or apoptosis, when they initially become cancerous. If the cells form sodium-selective pores in their membranes to begin the process of cell death, sodium ions can begin to enter the cells without regulation. What will likely happen to a resting cell membrane potential when sodium enters?
Tap to reveal answer
The pores formed are, according to the question, sodium selective. So it is unlikely that potassium concentration changes will be a major contributor to membrane potential changes. Since sodium is postively charged, and the ions entering are sodium, the inside of the cell will become more positively charged as sodium permeability goes up. We know that sodium will enter and potassium will leave due to the established gradients determined by sodium-potassium ATPase.
The pores formed are, according to the question, sodium selective. So it is unlikely that potassium concentration changes will be a major contributor to membrane potential changes. Since sodium is postively charged, and the ions entering are sodium, the inside of the cell will become more positively charged as sodium permeability goes up. We know that sodium will enter and potassium will leave due to the established gradients determined by sodium-potassium ATPase.
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What is the average resting potential of a nerve cell membrane?
What is the average resting potential of a nerve cell membrane?
Tap to reveal answer
Membrane potential is the difference between the electric potential inside the cell and the electric potential outside the cell. At rest, the membrane potential of most cells (including nerve cells) is between -70mV and -80mV due to the concentration of intracellular and extracellular potassium and sodium ions. The expulsion of sodium ions, in particular, contributes to positive charges outside the cell and lowers the charge inside.
Membrane potential is the difference between the electric potential inside the cell and the electric potential outside the cell. At rest, the membrane potential of most cells (including nerve cells) is between -70mV and -80mV due to the concentration of intracellular and extracellular potassium and sodium ions. The expulsion of sodium ions, in particular, contributes to positive charges outside the cell and lowers the charge inside.
← Didn't Know|Knew It →
The side of a plasma membrane receptor will bind to the ligand and the side of the plasma membrane receptor will initiate a cell response.
The side of a plasma membrane receptor will bind to the ligand and the side of the plasma membrane receptor will initiate a cell response.
Tap to reveal answer
In signal transduction, a ligand binds to the extracellular side of the plasma membrane receptor. This initiates a cellular response that is facilitated by the intracellular side. The intracellular region can activate a G protein, bind to an effector, or initiate other cellular responses. These responses often result in a signal cascade that affects transcription factors and alters gene expression.
In signal transduction, a ligand binds to the extracellular side of the plasma membrane receptor. This initiates a cellular response that is facilitated by the intracellular side. The intracellular region can activate a G protein, bind to an effector, or initiate other cellular responses. These responses often result in a signal cascade that affects transcription factors and alters gene expression.
← Didn't Know|Knew It →
Prions are the suspected cause of a wide variety of neurodegenerative diseases in mammals. According to prevailing theory, prions are infectious particles made only of protein and found in high concentrations in the brains of infected animals. All mammals produce normal prion protein, PrPC, a transmembrane protein whose function remains unclear.
Infectious prions, PrPRes, induce conformational changes in the existing PrPC proteins according to the following reaction:
PrPC + PrPRes → PrPRes + PrPRes
The PrPRes is then suspected to accumulate in the nervous tissue of infected patients and cause disease. This model of transmission generates replicated proteins, but does so bypassing the standard model of the central dogma of molecular biology. Transcription and translation apparently do not play a role in this replication process.
This theory is a major departure from previously established biological dogma. A scientist decides to test the protein-only theory of prion propagation. He establishes his experiment as follows:
Homogenized brain matter of infected rabbits is injected into the brains of healthy rabbits, as per the following table:
Rabbit 1 and 2: injected with normal saline on days 1 and 2
The above trials serve as controls.
Rabbit 3 and 4: injected with homogenized brain matter on days 1 and 2
The above trials use unmodified brain matter.
Rabbit 5 and 6: injected with irradiated homogenized brain matter on days 1 and 2
The above trials use brain matter that has been irradiated to destroy nucleic acids in the homogenate.
Rabbit 7 and 8: injected with protein-free centrifuged homogenized brain matter on days 1 and 2
The above trials use brain matter that has been centrifuged to generate a protein-free homogenate and a protein-rich homogenate based on molecular weight.
Rabbit 9 and 10: injected with boiled homogenized brain matter on days 1 and 2
The above trials use brain matter that have been boiled to destroy any bacterial contaminants in the homogenate.
Another experiment shows that PrPC reacts with hormones that circulate among nervous tissue. As a transmembrane protein, what kinds of hormones are most likely to interact with PrPC?
I. Peptide hormones
II. Catecholamines
III. Steroid Hormones
Prions are the suspected cause of a wide variety of neurodegenerative diseases in mammals. According to prevailing theory, prions are infectious particles made only of protein and found in high concentrations in the brains of infected animals. All mammals produce normal prion protein, PrPC, a transmembrane protein whose function remains unclear.
Infectious prions, PrPRes, induce conformational changes in the existing PrPC proteins according to the following reaction:
PrPC + PrPRes → PrPRes + PrPRes
The PrPRes is then suspected to accumulate in the nervous tissue of infected patients and cause disease. This model of transmission generates replicated proteins, but does so bypassing the standard model of the central dogma of molecular biology. Transcription and translation apparently do not play a role in this replication process.
This theory is a major departure from previously established biological dogma. A scientist decides to test the protein-only theory of prion propagation. He establishes his experiment as follows:
Homogenized brain matter of infected rabbits is injected into the brains of healthy rabbits, as per the following table:
Rabbit 1 and 2: injected with normal saline on days 1 and 2
The above trials serve as controls.
Rabbit 3 and 4: injected with homogenized brain matter on days 1 and 2
The above trials use unmodified brain matter.
Rabbit 5 and 6: injected with irradiated homogenized brain matter on days 1 and 2
The above trials use brain matter that has been irradiated to destroy nucleic acids in the homogenate.
Rabbit 7 and 8: injected with protein-free centrifuged homogenized brain matter on days 1 and 2
The above trials use brain matter that has been centrifuged to generate a protein-free homogenate and a protein-rich homogenate based on molecular weight.
Rabbit 9 and 10: injected with boiled homogenized brain matter on days 1 and 2
The above trials use brain matter that have been boiled to destroy any bacterial contaminants in the homogenate.
Another experiment shows that PrPC reacts with hormones that circulate among nervous tissue. As a transmembrane protein, what kinds of hormones are most likely to interact with PrPC?
I. Peptide hormones
II. Catecholamines
III. Steroid Hormones
Tap to reveal answer
Students should know that peptide hormones (and catecholamines, but this is not required to answer the question correctly as written here) interact with surface receptors and do not freely go through a membrane. They must interact with the transmembrane surface receptors to initiate a signal transduction cascade. In contrast, steroid hormones can bypass the transmembrance protein receptors by freely diffusing across the memberane, due to their small, nonpolar nature. In this case, only peptide hormones and catecholamines will require the facilitated diffusion mechanism provided by a transmembrane protein.
Students should know that peptide hormones (and catecholamines, but this is not required to answer the question correctly as written here) interact with surface receptors and do not freely go through a membrane. They must interact with the transmembrane surface receptors to initiate a signal transduction cascade. In contrast, steroid hormones can bypass the transmembrance protein receptors by freely diffusing across the memberane, due to their small, nonpolar nature. In this case, only peptide hormones and catecholamines will require the facilitated diffusion mechanism provided by a transmembrane protein.
← Didn't Know|Knew It →
Scientists use a process called Flourescent In-Situ Hybridization, or FISH, to study genetic disorders in humans. FISH is a technique that uses spectrographic analysis to determine the presence or absence, as well as the relative abundance, of genetic material in human cells.
To use FISH, scientists apply fluorescently-labeled bits of DNA of a known color, called probes, to samples of test DNA. These probes anneal to the sample DNA, and scientists can read the colors that result using laboratory equipment. One common use of FISH is to determine the presence of extra DNA in conditions of aneuploidy, a state in which a human cell has an abnormal number of chromosomes. Chromosomes are collections of DNA, the totality of which makes up a cell’s genome. Another typical use is in the study of cancer cells, where scientists use FISH labels to ascertain if genes have moved inappropriately in a cell’s genome.
Using red fluorescent tags, scientists label probe DNA for a gene known to be expressed more heavily in cancer cells than normal cells. They then label a probe for an immediately adjacent DNA sequence with a green fluorescent tag. Both probes are then added to three dishes, shown below. In dish 1 human bladder cells are incubated with the probes, in dish 2 human epithelial cells are incubated, and in dish 3 known non-cancerous cells are used. The relative luminescence observed in regions of interest in all dishes is shown below.
The bladder cells in dish 1 begin to undergo programmed cell death, or apoptosis, when they initially become cancerous. If the cells form sodium-selective pores in their membranes to begin the process of cell death, sodium ions can begin to enter the cells without regulation. What will likely happen to a resting cell membrane potential when sodium enters?
Scientists use a process called Flourescent In-Situ Hybridization, or FISH, to study genetic disorders in humans. FISH is a technique that uses spectrographic analysis to determine the presence or absence, as well as the relative abundance, of genetic material in human cells.
To use FISH, scientists apply fluorescently-labeled bits of DNA of a known color, called probes, to samples of test DNA. These probes anneal to the sample DNA, and scientists can read the colors that result using laboratory equipment. One common use of FISH is to determine the presence of extra DNA in conditions of aneuploidy, a state in which a human cell has an abnormal number of chromosomes. Chromosomes are collections of DNA, the totality of which makes up a cell’s genome. Another typical use is in the study of cancer cells, where scientists use FISH labels to ascertain if genes have moved inappropriately in a cell’s genome.
Using red fluorescent tags, scientists label probe DNA for a gene known to be expressed more heavily in cancer cells than normal cells. They then label a probe for an immediately adjacent DNA sequence with a green fluorescent tag. Both probes are then added to three dishes, shown below. In dish 1 human bladder cells are incubated with the probes, in dish 2 human epithelial cells are incubated, and in dish 3 known non-cancerous cells are used. The relative luminescence observed in regions of interest in all dishes is shown below.
The bladder cells in dish 1 begin to undergo programmed cell death, or apoptosis, when they initially become cancerous. If the cells form sodium-selective pores in their membranes to begin the process of cell death, sodium ions can begin to enter the cells without regulation. What will likely happen to a resting cell membrane potential when sodium enters?
Tap to reveal answer
The pores formed are, according to the question, sodium selective. So it is unlikely that potassium concentration changes will be a major contributor to membrane potential changes. Since sodium is postively charged, and the ions entering are sodium, the inside of the cell will become more positively charged as sodium permeability goes up. We know that sodium will enter and potassium will leave due to the established gradients determined by sodium-potassium ATPase.
The pores formed are, according to the question, sodium selective. So it is unlikely that potassium concentration changes will be a major contributor to membrane potential changes. Since sodium is postively charged, and the ions entering are sodium, the inside of the cell will become more positively charged as sodium permeability goes up. We know that sodium will enter and potassium will leave due to the established gradients determined by sodium-potassium ATPase.
← Didn't Know|Knew It →
What is the average resting potential of a nerve cell membrane?
What is the average resting potential of a nerve cell membrane?
Tap to reveal answer
Membrane potential is the difference between the electric potential inside the cell and the electric potential outside the cell. At rest, the membrane potential of most cells (including nerve cells) is between -70mV and -80mV due to the concentration of intracellular and extracellular potassium and sodium ions. The expulsion of sodium ions, in particular, contributes to positive charges outside the cell and lowers the charge inside.
Membrane potential is the difference between the electric potential inside the cell and the electric potential outside the cell. At rest, the membrane potential of most cells (including nerve cells) is between -70mV and -80mV due to the concentration of intracellular and extracellular potassium and sodium ions. The expulsion of sodium ions, in particular, contributes to positive charges outside the cell and lowers the charge inside.
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Which of the following molecules would not require a transport protein to cross the cellular plasma membrane?
Which of the following molecules would not require a transport protein to cross the cellular plasma membrane?
Tap to reveal answer
Nonpolar molecules and very small polar molecules can freely pass through the lipid bilayer, while large, polar molecules and ions need to be aided by transport proteins. Sodium and potassium are both charged ions that would not be able to cross the membrane. Glucose and citrate are too large, and also contain polar regions.
Carbon dioxide is the only answer choice that is both small and nonpolar enough to simply diffuse across the membrane.
Nonpolar molecules and very small polar molecules can freely pass through the lipid bilayer, while large, polar molecules and ions need to be aided by transport proteins. Sodium and potassium are both charged ions that would not be able to cross the membrane. Glucose and citrate are too large, and also contain polar regions.
Carbon dioxide is the only answer choice that is both small and nonpolar enough to simply diffuse across the membrane.
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The side of a plasma membrane receptor will bind to the ligand and the side of the plasma membrane receptor will initiate a cell response.
The side of a plasma membrane receptor will bind to the ligand and the side of the plasma membrane receptor will initiate a cell response.
Tap to reveal answer
In signal transduction, a ligand binds to the extracellular side of the plasma membrane receptor. This initiates a cellular response that is facilitated by the intracellular side. The intracellular region can activate a G protein, bind to an effector, or initiate other cellular responses. These responses often result in a signal cascade that affects transcription factors and alters gene expression.
In signal transduction, a ligand binds to the extracellular side of the plasma membrane receptor. This initiates a cellular response that is facilitated by the intracellular side. The intracellular region can activate a G protein, bind to an effector, or initiate other cellular responses. These responses often result in a signal cascade that affects transcription factors and alters gene expression.
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Engulfment of a foreign pathogen is an example of and engulfment of extracellular fluid is an example of ; both are forms of .
Engulfment of a foreign pathogen is an example of and engulfment of extracellular fluid is an example of ; both are forms of .
Tap to reveal answer
Recall that endocytosis is the process by which solid particles and fluid and transported from the outside to the inside of the cell by the use of vesicles.
When a cell engulfs a foreign pathogen, it creates a vesicle known as a phagosome. The phagosome carries the pathogen within the cell and fuses with a lysosome, which allows hydrolytic enzymes to digest the pathogen. The process of engulfing the pathogen in a vesicle is known as phagocytosis.
A cell can also form a vesicle around fluids in the extracellular space, via the process of pinocytosis. This vesicle can also fuse with lysosomes, allowing the breakdown of small particulates in the vesicle, which can then be used for energy.
Both phagocytosis and pinocytosis are forms of endocytosis.
Recall that endocytosis is the process by which solid particles and fluid and transported from the outside to the inside of the cell by the use of vesicles.
When a cell engulfs a foreign pathogen, it creates a vesicle known as a phagosome. The phagosome carries the pathogen within the cell and fuses with a lysosome, which allows hydrolytic enzymes to digest the pathogen. The process of engulfing the pathogen in a vesicle is known as phagocytosis.
A cell can also form a vesicle around fluids in the extracellular space, via the process of pinocytosis. This vesicle can also fuse with lysosomes, allowing the breakdown of small particulates in the vesicle, which can then be used for energy.
Both phagocytosis and pinocytosis are forms of endocytosis.
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Carbonic anhydrase is a very important enzyme that is utilized by the body. The enzyme catalyzes the following reaction:
A class of drugs that inhibits this enzyme is carbonic anhydrase inhibitors (eg. acetazolamide, brinzolamide, dorzolamide). These drugs are commonly prescribed in patients with glaucoma, hypertension, heart failure, high altitude sickness and for the treatment of basic drugs overdose.
In patients with hypertension, carbonic anhydrase inhibitors will prevent the reabsorption of sodium chloride 
in the proximal tubule of the kidney. When sodium is reabsorbed back into the blood, the molecule creates an electrical force. This electrical force then pulls water along with it into the blood. As more water enters the blood, the blood volume increase. By preventing the reabsorption of sodium, water reabsorption is reduced and the blood pressure decreases.
When mountain climbing, the atmospheric pressure is lowered as the altitude increases. As a result of less oxygen into the lungs, ventilation increases. From the equation above, hyperventilation will result in more 
being expired. Based on Le Chatelier’s principle, the reaction will shift to the left. Since there is more bicarbonate than protons in the body, the blood will become more basic (respiratory alkalosis). To prevent such life threatening result, one would take a carbonic anhydrase inhibitor to prevent the reaction from shifting to the left.
Carbonic anhydrase inhibitors are useful in patients with a drug overdose that is acidic. The lumen of the collecting tubule is nonpolar. Due to the lumen's characteristic, molecules that are also nonpolar and uncharged are able to cross the membrane and re-enter the circulatory system. Since carbonic anhydrase inhibitors alkalize the urine, acidic molecules stay in a charged state.
How will excess intake of a carbonic anhydratase inhibitor affect the blood's osmolarity if not properly regulated by the body?
Carbonic anhydrase is a very important enzyme that is utilized by the body. The enzyme catalyzes the following reaction:
A class of drugs that inhibits this enzyme is carbonic anhydrase inhibitors (eg. acetazolamide, brinzolamide, dorzolamide). These drugs are commonly prescribed in patients with glaucoma, hypertension, heart failure, high altitude sickness and for the treatment of basic drugs overdose.
In patients with hypertension, carbonic anhydrase inhibitors will prevent the reabsorption of sodium chloride
When mountain climbing, the atmospheric pressure is lowered as the altitude increases. As a result of less oxygen into the lungs, ventilation increases. From the equation above, hyperventilation will result in more
Carbonic anhydrase inhibitors are useful in patients with a drug overdose that is acidic. The lumen of the collecting tubule is nonpolar. Due to the lumen's characteristic, molecules that are also nonpolar and uncharged are able to cross the membrane and re-enter the circulatory system. Since carbonic anhydrase inhibitors alkalize the urine, acidic molecules stay in a charged state.
How will excess intake of a carbonic anhydratase inhibitor affect the blood's osmolarity if not properly regulated by the body?
Tap to reveal answer
As mentioned from the passage, carbonic anhydrase inhibitors will prevent water reabsorption at the proximal tubule. As a result, there will be less water in the blood. Osmolarity is a measurement of the amount of solutes divided by the fluid volume. Since the fluid volume will decrease, the osmolarity will increase.
As mentioned from the passage, carbonic anhydrase inhibitors will prevent water reabsorption at the proximal tubule. As a result, there will be less water in the blood. Osmolarity is a measurement of the amount of solutes divided by the fluid volume. Since the fluid volume will decrease, the osmolarity will increase.
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What is the function of cholestrol in the cell plasma membrane?
What is the function of cholestrol in the cell plasma membrane?
Tap to reveal answer
The major purpose of cholestrol in the plasma membrane is to maintain membrane fluidity. Carbohydrates and glycoproteins function in cell-to-cell recognition, and proteins function in the transport of particles through the membrane. Charged particles can't freely pass through the membrane unless it is through a carrier protein.
The major purpose of cholestrol in the plasma membrane is to maintain membrane fluidity. Carbohydrates and glycoproteins function in cell-to-cell recognition, and proteins function in the transport of particles through the membrane. Charged particles can't freely pass through the membrane unless it is through a carrier protein.
← Didn't Know|Knew It →
Prions are the suspected cause of a wide variety of neurodegenerative diseases in mammals. According to prevailing theory, prions are infectious particles made only of protein and found in high concentrations in the brains of infected animals. All mammals produce normal prion protein, PrPC, a transmembrane protein whose function remains unclear.
Infectious prions, PrPRes, induce conformational changes in the existing PrPC proteins according to the following reaction:
PrPC + PrPRes → PrPRes + PrPRes
The PrPRes is then suspected to accumulate in the nervous tissue of infected patients and cause disease. This model of transmission generates replicated proteins, but does so bypassing the standard model of the central dogma of molecular biology. Transcription and translation apparently do not play a role in this replication process.
This theory is a major departure from previously established biological dogma. A scientist decides to test the protein-only theory of prion propagation. He establishes his experiment as follows:
Homogenized brain matter of infected rabbits is injected into the brains of healthy rabbits, as per the following table:
Rabbit 1 and 2: injected with normal saline on days 1 and 2
The above trials serve as controls.
Rabbit 3 and 4: injected with homogenized brain matter on days 1 and 2
The above trials use unmodified brain matter.
Rabbit 5 and 6: injected with irradiated homogenized brain matter on days 1 and 2
The above trials use brain matter that has been irradiated to destroy nucleic acids in the homogenate.
Rabbit 7 and 8: injected with protein-free centrifuged homogenized brain matter on days 1 and 2
The above trials use brain matter that has been centrifuged to generate a protein-free homogenate and a protein-rich homogenate based on molecular weight.
Rabbit 9 and 10: injected with boiled homogenized brain matter on days 1 and 2
The above trials use brain matter that have been boiled to destroy any bacterial contaminants in the homogenate.
Since PrPC is a transmembrane protein, what are we most likely to find in the part of the protein that spans the membrane?
Prions are the suspected cause of a wide variety of neurodegenerative diseases in mammals. According to prevailing theory, prions are infectious particles made only of protein and found in high concentrations in the brains of infected animals. All mammals produce normal prion protein, PrPC, a transmembrane protein whose function remains unclear.
Infectious prions, PrPRes, induce conformational changes in the existing PrPC proteins according to the following reaction:
PrPC + PrPRes → PrPRes + PrPRes
The PrPRes is then suspected to accumulate in the nervous tissue of infected patients and cause disease. This model of transmission generates replicated proteins, but does so bypassing the standard model of the central dogma of molecular biology. Transcription and translation apparently do not play a role in this replication process.
This theory is a major departure from previously established biological dogma. A scientist decides to test the protein-only theory of prion propagation. He establishes his experiment as follows:
Homogenized brain matter of infected rabbits is injected into the brains of healthy rabbits, as per the following table:
Rabbit 1 and 2: injected with normal saline on days 1 and 2
The above trials serve as controls.
Rabbit 3 and 4: injected with homogenized brain matter on days 1 and 2
The above trials use unmodified brain matter.
Rabbit 5 and 6: injected with irradiated homogenized brain matter on days 1 and 2
The above trials use brain matter that has been irradiated to destroy nucleic acids in the homogenate.
Rabbit 7 and 8: injected with protein-free centrifuged homogenized brain matter on days 1 and 2
The above trials use brain matter that has been centrifuged to generate a protein-free homogenate and a protein-rich homogenate based on molecular weight.
Rabbit 9 and 10: injected with boiled homogenized brain matter on days 1 and 2
The above trials use brain matter that have been boiled to destroy any bacterial contaminants in the homogenate.
Since PrPC is a transmembrane protein, what are we most likely to find in the part of the protein that spans the membrane?
Tap to reveal answer
The core of the lipid bilayer of all eukaryotic cells contains lipid; therefore, transmembrane proteins have a hydrophobic-rich series of residues in the area that spans the membrane.
The core of the lipid bilayer of all eukaryotic cells contains lipid; therefore, transmembrane proteins have a hydrophobic-rich series of residues in the area that spans the membrane.
← Didn't Know|Knew It →
Prions are the suspected cause of a wide variety of neurodegenerative diseases in mammals. According to prevailing theory, prions are infectious particles made only of protein and found in high concentrations in the brains of infected animals. All mammals produce normal prion protein, PrPC, a transmembrane protein whose function remains unclear.
Infectious prions, PrPRes, induce conformational changes in the existing PrPC proteins according to the following reaction:
PrPC + PrPRes → PrPRes + PrPRes
The PrPRes is then suspected to accumulate in the nervous tissue of infected patients and cause disease. This model of transmission generates replicated proteins, but does so bypassing the standard model of the central dogma of molecular biology. Transcription and translation apparently do not play a role in this replication process.
This theory is a major departure from previously established biological dogma. A scientist decides to test the protein-only theory of prion propagation. He establishes his experiment as follows:
Homogenized brain matter of infected rabbits is injected into the brains of healthy rabbits, as per the following table:
Rabbit 1 and 2: injected with normal saline on days 1 and 2
The above trials serve as controls.
Rabbit 3 and 4: injected with homogenized brain matter on days 1 and 2
The above trials use unmodified brain matter.
Rabbit 5 and 6: injected with irradiated homogenized brain matter on days 1 and 2
The above trials use brain matter that has been irradiated to destroy nucleic acids in the homogenate.
Rabbit 7 and 8: injected with protein-free centrifuged homogenized brain matter on days 1 and 2
The above trials use brain matter that has been centrifuged to generate a protein-free homogenate and a protein-rich homogenate based on molecular weight.
Rabbit 9 and 10: injected with boiled homogenized brain matter on days 1 and 2
The above trials use brain matter that have been boiled to destroy any bacterial contaminants in the homogenate.
A scientist realizes that the PrPC protein functions in normal cells to help regulate the cell membrane potential. Her research shows that cells with PrPC have a normal resting membrane potential at around –70 mV. Activation of PrPC causes depolarization, with a peak depolarization at around +60 mV. What ion, also present in action potentials, is PrPC most likely allowing to flow freely?
Prions are the suspected cause of a wide variety of neurodegenerative diseases in mammals. According to prevailing theory, prions are infectious particles made only of protein and found in high concentrations in the brains of infected animals. All mammals produce normal prion protein, PrPC, a transmembrane protein whose function remains unclear.
Infectious prions, PrPRes, induce conformational changes in the existing PrPC proteins according to the following reaction:
PrPC + PrPRes → PrPRes + PrPRes
The PrPRes is then suspected to accumulate in the nervous tissue of infected patients and cause disease. This model of transmission generates replicated proteins, but does so bypassing the standard model of the central dogma of molecular biology. Transcription and translation apparently do not play a role in this replication process.
This theory is a major departure from previously established biological dogma. A scientist decides to test the protein-only theory of prion propagation. He establishes his experiment as follows:
Homogenized brain matter of infected rabbits is injected into the brains of healthy rabbits, as per the following table:
Rabbit 1 and 2: injected with normal saline on days 1 and 2
The above trials serve as controls.
Rabbit 3 and 4: injected with homogenized brain matter on days 1 and 2
The above trials use unmodified brain matter.
Rabbit 5 and 6: injected with irradiated homogenized brain matter on days 1 and 2
The above trials use brain matter that has been irradiated to destroy nucleic acids in the homogenate.
Rabbit 7 and 8: injected with protein-free centrifuged homogenized brain matter on days 1 and 2
The above trials use brain matter that has been centrifuged to generate a protein-free homogenate and a protein-rich homogenate based on molecular weight.
Rabbit 9 and 10: injected with boiled homogenized brain matter on days 1 and 2
The above trials use brain matter that have been boiled to destroy any bacterial contaminants in the homogenate.
A scientist realizes that the PrPC protein functions in normal cells to help regulate the cell membrane potential. Her research shows that cells with PrPC have a normal resting membrane potential at around –70 mV. Activation of PrPC causes depolarization, with a peak depolarization at around +60 mV. What ion, also present in action potentials, is PrPC most likely allowing to flow freely?
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Students should know the main players in establishing action potentials are K+ and Na+. Further, Na+ inward flow through open channels brings an action potential to a peak depolarization of about +60 mV, which is sodium's equilibrium potential
Students should know the main players in establishing action potentials are K+ and Na+. Further, Na+ inward flow through open channels brings an action potential to a peak depolarization of about +60 mV, which is sodium's equilibrium potential
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Each of the following membrane transport processes requires the use of specific proteins that allow for movement across the plasma membrane EXCEPT .
Each of the following membrane transport processes requires the use of specific proteins that allow for movement across the plasma membrane EXCEPT .
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Plasma membranes of the cell are permeable to molecules that pass through the phospholipid bilayer easily, namely small nonpolar molecules. Due to this specificity in permeability, membrane proteins are often required to transport molecules across the bilayer. Simple diffusion occurs when a substance passes through a membrane without the aid of an intermediary. All forms of facilitated transport, along with active transport, require the aid of specific membrane proteins. Thus, simple diffusion is the correct answer.
Plasma membranes of the cell are permeable to molecules that pass through the phospholipid bilayer easily, namely small nonpolar molecules. Due to this specificity in permeability, membrane proteins are often required to transport molecules across the bilayer. Simple diffusion occurs when a substance passes through a membrane without the aid of an intermediary. All forms of facilitated transport, along with active transport, require the aid of specific membrane proteins. Thus, simple diffusion is the correct answer.
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Which of the following best describes the composition of the plasma membrane of an animal cell?
Which of the following best describes the composition of the plasma membrane of an animal cell?
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The major components of the plasma membrane of an animal cell are lipids and proteins, with a small amount of carbohydrate components. The major lipid components are glycerophospholipids, sphingolipids, and some cholesterol. The amount of cholesterol varies depending upon certain factors, such as temperature, and helps maintain the fluidity of the membrane. Thus, the correct answer is phospholipids, sphingolipids, cholesterol, and protein, with some carbohydrate.
The major components of the plasma membrane of an animal cell are lipids and proteins, with a small amount of carbohydrate components. The major lipid components are glycerophospholipids, sphingolipids, and some cholesterol. The amount of cholesterol varies depending upon certain factors, such as temperature, and helps maintain the fluidity of the membrane. Thus, the correct answer is phospholipids, sphingolipids, cholesterol, and protein, with some carbohydrate.
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The fluidity of plasma membranes .
The fluidity of plasma membranes .
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Plasma membranes are composed of lipids and proteins, with a small amount of carbohydrates. The membrane is dependent upon these components to dictate its fluidity. An increase in unsaturated fatty acids leads to an increase in the fluidity of the membrane, while the increase of saturated fatty acids leads to a decrease in fluidity. Increasing the length of fatty acid chains leads to a decrease in fluidity. Thus, the correct answer is that it increases as the percent of unsaturated fatty acids increases.
Plasma membranes are composed of lipids and proteins, with a small amount of carbohydrates. The membrane is dependent upon these components to dictate its fluidity. An increase in unsaturated fatty acids leads to an increase in the fluidity of the membrane, while the increase of saturated fatty acids leads to a decrease in fluidity. Increasing the length of fatty acid chains leads to a decrease in fluidity. Thus, the correct answer is that it increases as the percent of unsaturated fatty acids increases.
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The cell is the most basic functional unit of life. Everything that we consider to be living is made up of cells, and while there are different kinds of cells, they all have some essential features that link them all together under the category of "life." One of the most important parts of a cell is the membrane that surrounds it, seperating it from the rest of the environment.
While organisms from the three main domains live in incredibly different environments, they all possess similar cell membranes. This phospholipid bilayer protects the cell, giving it a way to allow certain things in while keeping other things out. Though organisms from different domains have different kinds of fatty linkages in their membranes, they all serve this essential purpose.
Membranes contain all kinds of essential proteins and signal molecules that allow the inside of the cell to respond to the outside of the cell. In a multicellular eukaryote, this ability can be used to allow cells to communicate. In a bacterial colony, an extracellular signal could be used to signal other bacteria. Signals cascade through a series of molecular pathways that go from the outside of the cell all the way to the nucleus and back out again, giving the cell control on a genetic level. This allows cellular responses to be quick and effective, and it also allows the cell to control how long it stays in that state.
Some proteins span the cellular membranes multiple times, weaving in and out of them. What parts of the protein would be on the inside and outside of the membrane?
The cell is the most basic functional unit of life. Everything that we consider to be living is made up of cells, and while there are different kinds of cells, they all have some essential features that link them all together under the category of "life." One of the most important parts of a cell is the membrane that surrounds it, seperating it from the rest of the environment.
While organisms from the three main domains live in incredibly different environments, they all possess similar cell membranes. This phospholipid bilayer protects the cell, giving it a way to allow certain things in while keeping other things out. Though organisms from different domains have different kinds of fatty linkages in their membranes, they all serve this essential purpose.
Membranes contain all kinds of essential proteins and signal molecules that allow the inside of the cell to respond to the outside of the cell. In a multicellular eukaryote, this ability can be used to allow cells to communicate. In a bacterial colony, an extracellular signal could be used to signal other bacteria. Signals cascade through a series of molecular pathways that go from the outside of the cell all the way to the nucleus and back out again, giving the cell control on a genetic level. This allows cellular responses to be quick and effective, and it also allows the cell to control how long it stays in that state.
Some proteins span the cellular membranes multiple times, weaving in and out of them. What parts of the protein would be on the inside and outside of the membrane?
Tap to reveal answer
The phospholipid bilayer is made of two layers. Each layer has hyrophilic heads facing outwards and hydrophobic tails facing inwards. So, the parts facing the inside and outside of the cell are hydrophilic and so hydrophilic parts of proteins would go there. The inside of the membrane is all long, saturated, fatty carbon tails that are hydrophilic would contain the hydrophilic portions of the protein. Like goes to like.
The phospholipid bilayer is made of two layers. Each layer has hyrophilic heads facing outwards and hydrophobic tails facing inwards. So, the parts facing the inside and outside of the cell are hydrophilic and so hydrophilic parts of proteins would go there. The inside of the membrane is all long, saturated, fatty carbon tails that are hydrophilic would contain the hydrophilic portions of the protein. Like goes to like.
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The cell is the most basic functional unit of life. Everything that we consider to be living is made up of cells, and while there are different kinds of cells, they all have some essential features that link them all together under the category of "life." One of the most important parts of a cell is the membrane that surrounds it, seperating it from the rest of the environment.
While organisms from the three main domains live in incredibly different environments, they all possess similar cell membranes. This phospholipid bilayer protects the cell, giving it a way to allow certain things in while keeping other things out. Though organisms from different domains have different kinds of fatty linkages in their membranes, they all serve this essential purpose.
Membranes contain all kinds of essential proteins and signal molecules that allow the inside of the cell to respond to the outside of the cell. In a multicellular eukaryote, this ability can be used to allow cells to communicate. In a bacterial colony, an extracellular signal could be used to signal other bacteria. Signals cascade through a series of molecular pathways that go from the outside of the cell all the way to the nucleus and back out again, giving the cell control on a genetic level. This allows cellular responses to be quick and effective, and it also allows the cell to control how long it stays in that state.
One of the most important membrane proteins is the sodium-potassium pump. What would happen to a cell if this pump suddenly stopped working?
The cell is the most basic functional unit of life. Everything that we consider to be living is made up of cells, and while there are different kinds of cells, they all have some essential features that link them all together under the category of "life." One of the most important parts of a cell is the membrane that surrounds it, seperating it from the rest of the environment.
While organisms from the three main domains live in incredibly different environments, they all possess similar cell membranes. This phospholipid bilayer protects the cell, giving it a way to allow certain things in while keeping other things out. Though organisms from different domains have different kinds of fatty linkages in their membranes, they all serve this essential purpose.
Membranes contain all kinds of essential proteins and signal molecules that allow the inside of the cell to respond to the outside of the cell. In a multicellular eukaryote, this ability can be used to allow cells to communicate. In a bacterial colony, an extracellular signal could be used to signal other bacteria. Signals cascade through a series of molecular pathways that go from the outside of the cell all the way to the nucleus and back out again, giving the cell control on a genetic level. This allows cellular responses to be quick and effective, and it also allows the cell to control how long it stays in that state.
One of the most important membrane proteins is the sodium-potassium pump. What would happen to a cell if this pump suddenly stopped working?
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The sodium-potassium pump serves to move three sodium ions out of the cell and two potassium ion into the cell. These ions both have a plus one charge, so when the pump functions, it creates an environment where there are more solutes on the outside of the cell. if it stopped working, the cell would stop moving sodium out, and since it is a polar molecule, it can't cross the cell membrane on its own. There would be more solutes inside the cell than on the outside, and water would flow into the cell towards the higher solute concentration, causing the cell to swell and lyse.
The sodium-potassium pump serves to move three sodium ions out of the cell and two potassium ion into the cell. These ions both have a plus one charge, so when the pump functions, it creates an environment where there are more solutes on the outside of the cell. if it stopped working, the cell would stop moving sodium out, and since it is a polar molecule, it can't cross the cell membrane on its own. There would be more solutes inside the cell than on the outside, and water would flow into the cell towards the higher solute concentration, causing the cell to swell and lyse.
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The sodium-potassium pump helps to maintain electrolyte gradients through use of ATP. Which of the following best describes this type of transport?
The sodium-potassium pump helps to maintain electrolyte gradients through use of ATP. Which of the following best describes this type of transport?
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Active transport most correctly describes this type of movement, as it uses ATP as an energy source. In contrast, the other four choices are all different types of passive transport, constituting types of movement where no energy source is needed. Diffusion is simply the net movement of particles down their concentration gradient. Facilitated diffusion is a similar concept, but uses specialized transport proteins. Osmosis describes the movement of water, and lastly, filtration is the movement of both solute and water molecules.
Active transport most correctly describes this type of movement, as it uses ATP as an energy source. In contrast, the other four choices are all different types of passive transport, constituting types of movement where no energy source is needed. Diffusion is simply the net movement of particles down their concentration gradient. Facilitated diffusion is a similar concept, but uses specialized transport proteins. Osmosis describes the movement of water, and lastly, filtration is the movement of both solute and water molecules.
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