Resistors and Resistance - MCAT Chemical and Physical Foundations of Biological Systems

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Use the following information to answer questions 1-6:

The circulatory system of humans is a closed system consisting of a pump that moves blood throughout the body through arteries, capillaries, and veins. The capillaries are small and thin, allowing blood to easily perfuse the organ systems. Being a closed system, we can model the human circulatory system like an electrical circuit, making modifications for the use of a fluid rather than electrons. The heart acts as the primary force for movement of the fluid, the fluid moves through arteries and veins, and resistance to blood flow occurs depending on perfusion rates.

To model the behavior of fluids in the circulatory system, we can modify Ohm’s law of V = IR to ∆P = FR where ∆P is the change in pressure (mmHg), F is the rate of flow (ml/min), and R is resistance to flow (mm Hg/ml/min). Resistance to fluid flow in a tube is described by Poiseuille’s law: R = 8hl/πr4 where l is the length of the tube, h is the viscosity of the fluid, and r is the radius of the tube. Viscosity of blood is higher than water due to the presence of blood cells such as erythrocytes, leukocytes, and thrombocytes.

The above equations hold true for smooth, laminar flow. Deviations occur, however, when turbulent flow is present. Turbulent flow can be described as nonlinear or tumultuous, with whirling, glugging or otherwise unpredictable flow rates. Turbulence can occur when the anatomy of the tube deviates, for example during sharp bends or compressions. We can also get turbulent flow when the velocity exceeds critical velocity vc, defined below.

vc = NRh/ρD

NR is Reynold’s constant, h is the viscosity of the fluid, ρ is the density of the fluid, and D is the diameter of the tube. The density of blood is measured to be 1060 kg/m3.

Another key feature of the circulatory system is that it is set up such that the organ systems act in parallel rather than in series. This allows the body to modify how much blood is flowing to each organ system, which would not be possible under a serial construction. This setup is represented in Figure 1.

Circulatory_system_circuit

Assume that in Figure 1 R1 = 1/2 mmHg/ml/min, R2 = 2 mmHg/ml/min, R3 = 4 mmHg/ml/min, and R4 = 4 mmHg/ml/min.

The pressure generated by the left ventricle is 100mmHg and the pressure generated from the right ventricle is 50mmHg. What is the rate of flow across R3?

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Answer

For a parallel circuit, voltage remains constant. Analogously, pressure remains constant in this scenario. If we know the pressure and the resistance, we can find the current flow through the resistor by using ∆P = FR.

In this case, we will use only the left ventricle pressure, since that is the pressure pumped to the rest of the body, whereas the right ventricle only pumps to the lungs. Using ∆P = FR we can rearrange this to give us F = ∆P/R. Plugging in the numbers we can solve for F.

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