Endocrine and Immune Systems - NCLEX-PN

Mast cells are rich in granules that contain high concentrations of heparin, histamine, and trypsin, among other preformed proteases. These granules also contain serotonin and various eicosanoids. The function of mast cells is primarily to regulate immune (inflammatory) responses to allergens.

While all of the cells listed may have some indirect involvement in the overall response to a parasitic infection, eosinophils are the only immune cells that are specialized to respond to multicellular parasites, especially helminths such as hookworms and pinworms.

Macrophages, the main blood cells responsible for phagocytosis of debris, bacteria, and virally infected cells, are part of the nonspecific immune response. While they are able to recognize self versus non-self proteins, they are not uniquely sensitive to any particular non-self protein type. Rathe, they phagocytose foreign matter as well as cellular debris. Plasma cells, memory cells, and CD8 T cells are all lymphocytes, and as such they are all part of the adaptive or "specific" immune system, meaning that they are uniquely sensitive to particular pathogenic proteins.

While all of the enzymes listed are present in saliva, lysozyme is the only enzyme listed that has antibacterial properties. This enzyme, present not only in saliva but also in tears, sweat, and breast milk, damages bacterial cell walls, making it an important part of the innate immune system. Amylase breaks down carbohydrates, lipase breaks down lipids, and kallikrein breaks down proteins.

Selenium is essential for conversion of T4 to T3. Deiodinase enzymes, which remove iodine from T4 during conversion into T3, are selenium dependent. Tyrosine and iodine are both required for synthesis of T4, and iron is the cofactor for conversion of phenylalanine into tyrosine.

Calcitonin is produced by the parafollicular (c cells) of the thyroid as a response to elevated blood calcium levels. Calcitonin reduces plasma calcium by inhibiting osteoclast activity and stimulating osteoblasts to deposit more bone. Parathyroid hormone has the opposite effect - it acts to increase calcium levels when serum calcium decreases. While they may ultimately affect serum calcium levels, thyroid hormone and cortisol are not directly involved in calcium homeostasis.

Thyroid-stimulating hormone (TSH) is produced in the anterior pituitary. Somatostatin, dopamine, and gonadotropin releasing hormone are all hypothalamic hormones. Somatostatin is also secreted by the pancreas, and slows down digestive processes. To remember the hormones of the anterior pituitary, use the following mnemonic: FLAT PEG, Follicle-stimulating hormone, Luteinizing hormone, Adrenocorticotropic hormone, Thyroid-stimulating hormone, Prolactin, Endorphins, Growth hormone.

Calcitonin is produced by the thyroid gland. The hormone plays an important role in lowering blood calcium levels. It is also synthesized as a drug and used in the treatment of hypercalcemia. The other three hormones are indeed secreted by the islets of Langerhans in the pancreas. Insulin, secreted by the beta cells lowers blood sugar, glucagon, secreted by the alpha cells, increases blood sugar, and somatostatin, secreted by the gamma cells regulates digestive and metabolic processes. Lipase is not a hormone, but an enzyme that facilitates the breakdown of lipids. The pancreas does indeed secrete lipase.

Endocrine glands secrete hormones into the blood. The endocrine glands include the ovaries, testes, hypothalamus, thyroid, pituitary, adrenal glands, pancreas, the pineal gland, and others. Salivary glands are considered exocrine glands. Exocrine glands secrete substances through ducts to the body surface or into body cavities, such as the mouth in the case of salivary glands.

Oxytocin is produced by the hypothalamus, and is released by the posterior pituitary. Women experience an increased level of oxytocin during labor, after birth, and while breastfeeding. It helps to increase uterine contractility, aiding in the delivery process and preventing hemorrhage after birth. Progesterone and estrogen are hormones released from the ovary. Estrogen is has many effects on the body, one of which is the development of sex characteristics in females. Progesterone is important in regulation of the uterine lining. Prolactin is made by the anterior pituitary gland and functions in the production on breast milk.

Epinephrine is the only hormone of those listed that is produced by the adrenal medulla. The adrenal medulla is the center of the adrenal gland. Antidiuretic hormone is produced by the posterior pituitary. Calcitonin is produced by the thyroid. Thyroid-stimulating hormone is secreted from the anterior pituitary, as is follicle-stimulating hormone.

All of these are correct effects of parathyroid hormone. The kidneys resorb calcium and as a result, less is released into the urine. The intestines absorb additional calcium from food and calcium is released from the bone through the work of osteoclasts.

Catecholamines are hormones produced by the adrenal medulla. Adrenal glands are located above each kidney. Catecholamines may also function as neurotransmitters, important chemical messengers. They regulate the sympathetic nervous system's response to stress.

Thyroid-stimulating hormone (TSH) is produced by the anterior pituitary. TSH causes the thyroid to release thyroid hormones (T3 and T4). A TSH blood test is often ordered to diagnose hypoactive thyroid.

The thyroid gland is located (in front) anterior to the trachea. The parathyroid glands are located on the backside on the thyroid. The thyroid is stimulated in response to TSH produced by the anterior pituitary. It will then secrete T3 and T4 although T3 is more potent and produced in a lesser quantity. Calcitonin, a hormone which decreases blood calcium levels, is also produced by the thyroid.

Aldosterone is a hormone secreted by the adrenal glands. Serum aldosterone levels vary throughout the day. Aldosterone presence is highest in the morning. Of the answer choices, 7 AM is the best choice. A physician may have the patient come to the office at a specific time of day for this reason.

The pineal gland is responsible for regulating melatonin. It is not known at this time to secrete any other hormone. Melatonin is thought to play a critical role in the regulation of the circadian rhythm. Cortisol is secreted by the adrenal cortex and is involved in regulating the stress response. Vitamin D become activated in three steps. First, ultraviolet light in the skin begins the process, then the process continues in the liver, and is completed in the kidney. The active form of vitamin D increases calcium absorption in the gut, decreases calcium loss in urine, and increases calcium mobilization from bone. Vasopressin is also known as antidiuretic hormone, and functions in water retention. Leptin is a hormone secreted by adipose tissue that tells the body that it is full, and not hungry.

Leptin is secreted by adipose cells, and acts on the arcuate nucleus of the lateral hypothalamus to promote the synthesis of alpha-MSH (alpha-melanocyte-stimulating hormone), which is a hunger suppressant. It also binds to receptors for neuropeptide Y (NPY), a powerful hunger promoter, in the arcuate nucleus.

None of the other hormones listed, while all involved in nutrient and blood sugar metabolism, directly trigger feeling of satiety.

Leptin, the hormone responsible for feelings of satiety, goes down during times of fasting, with high testosterone, during sleep deprivation, and during periods of prolonged exercise or physical training.