Neural Pharmacology - NCLEX-PN

Fluoxetine is an example of a selective serotonin re-uptake inhibitor (SSRI). SSRI's limit the amount of serotonin that the presynaptic cell that secreted it, cat re-uptake. This increases the time and amount that serotonin is in the synaptic cleft, and bound to postsynaptic receptors, leading to anti-depressant properties. The other drugs are all antidepressants, but are sold under other names.

Clomipramine is a tricyclic antidepressant. Drugs in this class function primarily by blocking serotonin and norepinephrine transporters, resulting in an increase in the levels of these neurotransmitters in the synapse, and thus an increase in their effects due to staying bound to postsynaptic receptors for longer.

Trazodone is a serotonin antagonist and reuptake inhibitor (SARI). These drugs work by increasing the release and inhibiting the reuptake of serotonin in the synaptic space, thus increasing the effect of serotonin.

Aripiprazole is an atypical antipsychotic. It acts as a partial dopamine agonist and an agonist to multiple 5-HT (serotonin) receptors.

Quetiapine is classified as an atypical antipsychotic. Quetiapine is a powerful antihistamine and has pharmacological action at many receptor types: it is a serotonin, dopamine, and adrenergic antagonist.

Bupropion is an antidepressant used for smoking cessation. None of the other medications listed are used for smoking cessation.

Sertraline, paroxetine, and Citalopra are all selective serotonin re-uptake inhibitors (SSRIs). This class of drug works by blocking serotonin re-uptake in the synapse, thus increasing post-synaptic serotonin stimulation. They are one of the most widely used class of antidepressants in the United States and many parts of the world.

Zolpidem is a short acting nonbenzodiazepine hypnotic. It's actions are similar to benzodiazepine drugs in that it stimulates GABAa receptors at the same location as benzodiazepines. It is used in insomnia for initiating sleep, though it's short half life (3 hours) means it is not generally considered effective for maintaining sleep.

Diazepam is a benzodiazepine. This class of drugs works by potentiating the effects of GABA, our primary inhibitory neurotransmitter, at the GABAa receptor.

All of the answers given are common anticonvulsant medications except risperidone, which is a second generation atypical antipsychotic used in schizophrenia and bipolar disorder.

Lamotrigine carries a black box warning about the following side effects:

• Stevens–Johnson syndrome
• Toxic epidermal necrolysis
• DRESS syndrome (drug reaction/rash with eosinophilia and systemic symptoms)
• Aseptic meningitis

Phenelzine is a monoamine oxidase inhibitor (MAOI). Drugs in this class work by inhibition of monoamine oxidase enzymes, the enzymes responsible for the break down of serotonin, dopamine, and adrenaline.

Bromocriptine is a dopamine agonist used in the treatment for Parkinson's disease, pituitary tumors, and type 2 diabetes.

All of the listed options are side effects of haloperidol, but tardive dyskinesia (TD) is the only one that manifests with involuntary, dyskinetic movements in their face, lips, tongue, trunk, and extremities. TD more frequently occurs among elderly female patients taking long-term dopamine-antagonist medications. Dizziness, weakness, convulsions, seizures, and anxiety are also side effects of haloperidol. Neuroleptic Malignant Syndrome presents with fever and high/unstable blood pressure, muscle cramps and tremors, altered mental status (such as delirium, agitation, or a coma).

The correct answer is "benzodiazepine," as lorazepam, also known as Ativan, is a benzodiazepine drug. Benzodiazepines act by increasing the efficacy of the neurotransmitter, GABA, when it acts upon its particular receptors. They have potent anti-anxiety properties, among other properties, and are frequently given during the initial phase of a panic attack to calm the patient.

On the other hand, the other choices are incorrect. Phenobarbital is an example of a barbiturate. Proproanolol is an example of a beta-blocker. Tamsulosin is an example of an alpha-blocker. Methamphetamine is an example of an amphetamine.

Clients taking Paroxetine may experience withdrawal and continuation syndrome. To minimize symptoms, taper the medication over a period of 3 or more weeks.

Fluoxetine is an example of a selective serotonin re-uptake inhibitor (SSRI). SSRI's limit the amount of serotonin that the presynaptic cell that secreted it, cat re-uptake. This increases the time and amount that serotonin is in the synaptic cleft, and bound to postsynaptic receptors, leading to anti-depressant properties. The other drugs are all antidepressants, but are sold under other names.

Clomipramine is a tricyclic antidepressant. Drugs in this class function primarily by blocking serotonin and norepinephrine transporters, resulting in an increase in the levels of these neurotransmitters in the synapse, and thus an increase in their effects due to staying bound to postsynaptic receptors for longer.

Trazodone is a serotonin antagonist and reuptake inhibitor (SARI). These drugs work by increasing the release and inhibiting the reuptake of serotonin in the synaptic space, thus increasing the effect of serotonin.